ASBESTOS: Asbestos is a greeck word meaning “UNQUENCHABLE”.In general if coal is lot of dust and little
fibrosis,asbestos is little dust and lot of fibrosis prolonged exposure for number of years to asbestos dust produces
‘three’ types of severe diseases-‘ASBESTOSIS OF LUNGS,PLEURAL DISEASES and TUMOURS’.
Due to its fibre strength and heat resistant properties,asbestos has been used for a wide range ofmanufactured GOODS,mostly
in building materials like ROOFING SHINGLES,CEILING and FLOOR TILES,paper products and asbestos cement products,
friction products like AUTOMOBILES CLUTCH,BRAKES and TRANSMISSION PARTS,heat resistant fibries,Gaskets and Coatings.
when asbestos containing materials are damaged or disturbed ,then by REPAIRING,REMODELING or DEMOLITION
activities,microscopic fibers become air borne and can be inhaled into lungs, causing significant health problems.
Exposure to people who work in industries that mine or make asbestos products and those living near
industries are more prone to asbestos disorders.
ILL EFFECTS OF ASBESTOS OVER HEALTH: Over exposure to asbestos for more than a decade may produce
‘ASBESTOS OF LUNGS,PLEURAL LESIONS and CERTAIN TUMOURS.The inhaled asbestos fibers are phagocytosed by alveolar macrophages
from where they reach the interstitum.Some of the engulfed dust is transported via lymphatics to the pleura and regional lymph nodes.
The asbestos-laden macrophages release “CHEMOATTRACTANTS”for neutrophills and for more macrophages,thus inciting
cellular reaction around them.these asbestos fibers are coated with glycoprotein and endogenous HAEMOSIDERIN to
produce characterstic ‘BEADED’ or ‘DUMBELL’shaped asbestos bodies.
These asbestos are fibrogenic and results in INTERSTITIAL FIBROSIS.Fibroblastic proliferation may occur
via macrophage derived growth factor such as “INTERLEUKIN-1”.alternatively,fibrosis may occur as a reparative
response to tissue injury by lysosomal enzymes released from macrophages and neutrophills or by toxic free radicals.
A few immunological abnormalities such ‘ANTI NUCLEAR ANTIBODIES’ and ‘RHEUMATOID FACTOR’have been found in cases of
asbestosis but their role in the genesis is not yet clear…